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Furthermore, obesity-associated gut dysbiosis has been linked to the release of various bacterial toxins into the bloodstream, which can exert an influence on the CNS ( Pseudoflavonifractor , bacteria associated with impaired energy metabolism and insulin sensitivity found over-represented in PD patients gut (Kim et al., 2022

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Importantly, enterocyte-derived revSCs could generate CBCs in lineage tracing experiments of villus culture coupled with organoid transplantation model 23,24 , organoid replating assay 14 , and 5-FU enteritis model 25,26 , providing evidence that fetal reversion serves as an entry point to spatial plasticity